The Helix research group
Research themes
Work in progress and results
Software and databases
News from Helix
Home page
Site map Mail to Helix
Genetic Network Analyzer: Qualitative simulation of genetic regulatory networks
Bioinformatics, 19(3): 336-344, 2003
H. de Jong, J. Geiselmann, C. Hernandez, M. Page

Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes.

Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis.

Full text

Recommended by Faculty of 1000

    Top of page   Home page  Prepare to print