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Modeling and simulation of genetic regulatory networks
The modeling and simulation of genetic regulatory networks are currently subject to two major constraints: incomplete knowledge about biochemical reaction mechanisms and a general absence of quantitative information on kinetic parameters and molecular concentrations. We have developed a qualitative modeling and simulation method that is able to satisfy the above constraints. The method has been implemented in the computer tool Genetic Network Analyzer (GNA), and used for the analysis of various prokaryote regulatory networks.
Method for qualitative modeling and simulation
Implementation and application of the method
Mathematical problems in the analysis of genetic regulatory networks
Validation of genetic regulatory networks
Identification of genetic regulatory networks from experimental data
Nutritional stress response of Escherichia coli and Synechocystis
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