The Helix research group
Research themes
Work in progress and results
Publications
Software and databases
News from Helix
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The Helix research group
  Context and situation
    Where are Rh�ne-Alpes, Grenoble, Lyon and Geneva ?
    Mountains all around...
    A short presentation of the french research system
  Research activities
    Comparative genomics
    Evolutionary biology
    String algorithmics
    Tree and graph algorithmics
    Data and knowledge modeling
  Partnerships
    Genostar
    Sanofi-Synth�labo Recherche, Toulouse
    GenoStar consortium
    Swiss Institute of Bioinformatics (SIB)
    CEA/LCP, Grenoble
    Departamento de Ci�ncia da Computa��o, Instituto de Matem�tica e Estat�stica, Universidade de S�o Paulo, Brazil
    Universit� Joseph Fourier - CEA Grenoble - INRIA Rh�ne-Alpes
    Rh�ne-Alpes Genopole
    XRCE (Xerox Research Center Europe)
    ORIEL IST project
    CCSTI, Grenoble
    Laboratoire Adaptation et Pathog�nie des Microorganismes, FRE 2620, CNRS/UJF
  Teaching activities
    Continuing education in bioinformatics
    The bioinformatics optional course of the master of computer science at university Joseph Fourier
  Members
    Group leader
      Viari, Alain
    Researchers and professors
      Daubin, Vincent
      De Jong, Hidde
      Duret, Laurent
      Gautier, Christian
      Genoud, Philippe
      Gouy, Manolo
      Gueguen, Laurent
      Kahn, Daniel
      Lobry, Jean
      Marais, Gabriel
      Mouchiroud, Dominique
      Mousset, Sylvain
      Page, Michel
      Perri�re, Guy
      Rechenmann, Fran�ois
      Ropers, Delphine
      Sagot, Marie-France
      Tannier, Eric
      Zi�belin, Danielle
    Software and system engineers
      Delmotte, St�phane
      Iltis, Agn�s
      L�py, Nathalie
      Monte, R�gis
      Ribes, Emma
      Spataro, Bruno
    Post-doctoral students
      Aouacheria, Abdel
      Baldazzi, Valentina
      Boyer, Fr�d�ric
      Dufayard, Jean-Fran�ois
      Penel, Simon
    PhD students
      Arigon, Anne-Muriel
      Batt, Gr�gory
      Calteau, Alexandra
      Descorps-Decl�re, St�phane
      Drulhe, Samuel
      Khelifi, Adel
      Lacroix, Vincent
      Melo de Lima, Christelle
      Meunier, Julien
      Navratil, Vincent
      Palmeira, Leonor
      Semon, Marie
    External members
      Coissac, Eric
      Lachaize, Corinne
      Morgat, Anne
    Secretarial staff
      De Coninck, Fran�oise
      Pieri, Marie-Jos�phe
  Former members
    Software engineers
      Bruley, Christophe
      Bruley, St�phane
      Brun, Antoine
      Ciron, Pierre-Emmanuel
      Dupierris, V�ronique
      Faroux, Ga�l
      Faucherand, Gilles
      Hernandez, C�line
      R�guer, Erwan
      Silvestre, Thimoth�e
      Wessel, Erik
    Post-doctoral students
      Hughes, Sandrine
      Merienne, St�phanie
      Pillet, Violaine
      Pisanti, Nadia
      Provencher, S�bastien
      Rivi�re-Rolland, H�l�ne
      Tavar�s, Raquel
    PhD students
      Piganeau, Gwena�le
      Ponger, Lo�c
      Proux, Denys
      Rizzon, Car�ne
      Thormarat, Fabienne
      Zelwer, Marina
    External members
      Dina, Jean
      Fanchon, Eric
      M�tivier, Charles
      Nugues, Estelle
                   
Research themes
  Evolution of species and gene families
    Reconciliation of species and gene trees
  Spatial organization of genomic information
    Isochores
  Syntaxic and functionnal genome annotation
    Markov models
  Proteomics
    Mass spectometry (MS vs MS/MS)
    Peptide Sequence Tag (PST)
  Modeling and simulation of genetic regulatory networks
    Overview
    Methods for modeling and simulation
    Aim of research
  Information extraction from texts
    Examples of sentences
                   
Work in progress and results
  Evolution of gene and gene families
    Phylogenetic tree conciliation
  Spatial organization of genomic information
    GEM
  Syntaxic and functionnal genome annotation
    GenoStar
  Proteomics
    From MS/MS spectra to PSTs
    From PSTs to protein identification
    From PSTs to gene localization
    Validation of PepLine
  Modeling and simulation of genetic regulatory networks
    Method for qualitative modeling and simulation
    Implementation and application of the method
    Mathematical problems in the analysis of genetic regulatory networks
    Validation of genetic regulatory networks
    Identification of genetic regulatory networks from experimental data
    Nutritional stress response of Escherichia coli and Synechocystis
  Information extraction from text
    The identification of names in a perfect world
    Identification of gene, proteins and species names
                   
Publications
  Publications by year
  Publications by author
                   
Software and databases
  The GenoStar integrated bioinformatics platform for exploratory genomics
  GEB: GenoExpertBacteria
  GNA: Genetic Network Analyzer
  PepLine: high throughput proteomics
  Herbs: checking the consistency of proteome annotations
  ISee: In Silico biology e-learning environment
  BOX: XML specifications of genomic data
  AROM: entity-relationship knowledge modeling
  ISee
    Call for partnership
    Dotplot
    Gene finding strategy in bacterial sequences
    How to get ISee?
    Interactive lessons
    Introducing the genetic code and the translation process
    ISee copyright notice
    Pattern matching algorithms
    Sequence alignment
    Statistical analysis of DNA sequences
  GenoStar
    Differential features of GenoStar
    GenoAnnot
    GenoBool
    GenoLink
    Hardware and software requirements
    How to get GenoStar?
  GNA
    Overview of GNA
    Installing GNA
    Using GNA
    Appendices
    Copyright notice GNA
  BOX
    Documentation
    Modules
    Presentation of BOXml
  GEB
    GEB Copyright notice
    GEB system requirements
  Herbs
    The graphical user interface
    The inference engine
  AROM
    Examples of biological knowledge modeling
                   
News from Helix
  Initiez-vous � la bioinformatique !
  Les d�fis de la biologie int�grative
  This website is outdated.
  Software and database releases
  Talks, seminars, poster presentations,...
  PhD and Master thesis defenses
    PhD thesis defense - Gregory Batt - February 24th - 2pm - INRIA Rh�ne-Alpes (Montbonnot, Grenoble, France)
    PhD thesis defense, Car�ne Rizzon, Universit� Claude Bernard (Lyon 1), September 19th, 2003
    PhD thesis defense, Fr�d�ric Boyer, Universit� Joseph Fourier (Grenoble), July 9th, 2004
    PhD thesis defense, Jean-Fran�ois Dufayard, Universit� Joseph Fourier (Grenoble), December 14th, 2004
    PhD thesis defense, Lo�c Ponger, Universit� Claude Bernard (Lyon 1), September 16th, 2003
  Training and job opportunities
                   
What is bioinformatics?
  A short introduction to bioinformatics
    The first genome projects
    Whole genome sequencing
    Genomic databases
    The problem of heterogeneous databases
    Searching for homology through similarity of sequences
    Finding genes in procaryotic genomes
    Finding genes in eucaryotic genomes
    Inferring gene functions from homology relationships
    The quest for gene fonction has not yet found an algorithmic solution
    Modeling and simulating gene interaction networks and metabolic pathways
    Biological data and knowlege need to be formalized
  Another, more recent, introduction to bioinformatics (in French)
    La bioinformatique, un dossier du site Interstices
  A series of five papers (in French) published by the Biofutur journal in March 2007
    Editorial of the March 2007 issue of Biofutur journal
    The abstracts of the papers
  A series of five pedagogical papers on bioinformatics
    In silico annotation of genomic sequences
    Biological data and knowledge modeling
    Modelling, analysis and simulation of gene networks
    Comparative genomic mapping in mammals
    Molecular phylogeny and evolution
  A series of nine papers published (in French) by the Biofutur journal in 2005
    Editorial of the January 2005 issue of the Biofutur journal
    The abstracts of the papers (in French)
  Interactive applets to discover some basic bioinformatics algorithms
    Recherche de g�nes dans un g�nome bact�rien
    Alignement optimal de deux s�quences biologiques
  Some key terms of molecular biology and their definition (in French)
    Macro-mol�cules, ADN, ARN, prot�ine, acide amin�,...
    G�nes, g�nome, g�nomique,...
    Code g�n�tique, traduction, ARNm, ARNt, ARNr,...
    Eucaryotes/procaryotes, exons/introns, �pissage,...
    Transcription, transcriptome, puces � ADN,...
    Prot�ines, prot�omique, structure, fonction,...
    R�gulation, signaux, r�seaux,...
  Bioinformatics as a research domain
    Genomic and post-genomic data and knowledge modeling
  Glossary
  Bibliography
    The art of Genes - How organisms make themselves
    Gene regulation and metabolism : postgenomic computational approaches
    Error-tolerant identification of peptides in sequence databases by peptide sequence tags.
                   
What's new in bioinformatics?
                   
Related links
  PBIL - P�le BioInformatique Lyonnais
  Adebag
  ExPASy proteomics server
  IBCP - Institute of Biology and Chemistry of Proteins
  ARTEB Rh�ne-Alpes - Agency for the development of medical technologies and biotechnology
  Infobiogen
  Soci�t� Fran�aise de BioInformatique (SFBI)
  EBI - European Bioinformatics Institute
  NCBI - National Center for Biotechnology Information
  NAR (Nucleic Acids Research) journal
  GIW - International Conference on Genome Informatics
  PSB - Pacific Symposium on Biocomputing
  S* Alliance - BioInformatics Education
  ISCB - International Society for Computational Biology
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