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Analysis and verification of qualitative models of genetic regulatory networks: A model-checking approach |
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| G. Batt, D. Ropers, H. de Jong, J. Geiselmann, R. Mateescu, M. Page and D. Schneider |
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Methods developed for the qualitative simulation of dynamical systems have turned out to be powerful tools for studying genetic regulatory networks. A bottleneck in the application of these methods is the analysis of the simulation results.
In this paper, we propose a combination of qualitative simulation and model-checking techniques to perform this task systematically and efficiently. We apply our approach to the analysis of the complex network controlling the nutritional stress response in the bacterium Escherichia coli.
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